Selective C-O Coupling Reaction of N-Methoxy Arylamides and Arylboronic Acids Catalyzed by Copper Salt

Herein, we report a copper-catalyzed C-O cross-coupling of N-methoxy amides and arylboronic acids for the synthesis aryl-N-methoxy arylimides. The fully selective O-arylation is found to be greatly prompted by inexpensive commercially available CuI. reaction conditions tolerate variety functional groups promote different reactivities depending on electronic steric properties distorted substrates.